Nano photonics and its applications

Fixler's lab deals with theoretical and practical models for reconstructing the optical properties of participating media by nano photonic tools. Our theory is based on a robust generalization of the diffusion theory; Gerchberg-Saxton algorithm; dipole-dipole approximation and other methods. On the practical side we use lasers, LEDs and microscopes.

Meet the Team

Research

Fixler's lab develops theoretical and practical models for reconstructing optical properties of complex media using nanophotonic tools. By generalizing diffusion theory and employing advanced algorithms with lasers and microscopes, the lab overcomes the challenges of nonhomogeneous human tissue. Instead of traditional imaging, the research focuses on detection via diffusion reflection profiles, nanoparticles, and fluorescence parameters. These non-invasive methods enable the characterization of pathologies like cancer and vascular diseases, offering significant potential for early diagnosis and personalized treatment.

The lab bridges the gap between fundamental physics and clinical application through extensive interdisciplinary collaborations. By integrating innovative nanophotonic sensors with real-time data analysis, we aim to transform these optical techniques into portable, cost-effective diagnostic tools for bedside medicine.

Yuval Haibi completes MSc with distinction

Congratulations to Yuval Haibi on completing his MSc degree with a final grade of 95. Yuval’s research contributed to the development of integrated DRS and IMOPE methods for quantitative optical-property extraction in scattering media.

Fixler Lab awarded new ISF grant

Fixler Lab was awarded a new Israel Science Foundation research grant. The project will develop optical methods for characterizing heterogeneous multilayer scattering media using indirect phase-related metrics extracted from diffusely reflected light.

New collaborative project with UCI

Fixler Lab was awarded a new collaborative project with Prof. Zhongping Chen at the University of California, Irvine. The project, “Quantitative Decoupling of Absorption and Scattering via IPL-OCT Integration,” will explore integration of IPL-based optical decoupling with OCT-based imaging and sensing approaches. Link

Invited talk at Optica ImageSense Congress

Prof. Dror Fixler delivered an invited talk at Optica ImageSense Congress 2026 titled “High Speed Cuffless Blood Pressure Measurement with the Iso-pathlength (IPL) Point.” The presentation highlighted the lab’s recent progress toward self-calibrated optical monitoring of blood pressure and other physiological parameters. Link

New JBO publication on IPL in endoscopic geometry

Fixler Lab published new work in the Journal of Biomedical Optics on endoscopic iso-pathlength self-calibration. The study extends the IPL concept to hollow cylindrical structures relevant to endoscopic geometries, supporting future direction-resolved retrieval of tissue optical properties. Link

Prof. Fixler appointed SPIE BiOS Track Chair

Prof. Dror Fixler was appointed Track Chair for the Nano/Biophotonics track at SPIE BiOS, part of SPIE Photonics West. This appointment reflects the lab’s ongoing contribution to nanophotonics, biophotonics, biomedical optics, and optical sensing. Link

Prof. Fixler appointed Israel representative to international pulse oximetry standards working groups

Prof. Dror Fixler was officially appointed by the Standards Institution of Israel (SII) to serve as Israel’s representative to ISO/TC 121/SC 3/JWG 10 and IEC/TC 62/SC 62D/JWG 5, the joint international working groups focused on pulse oximetry standards. This activity connects the lab’s research in pulse oximetry, skin-tone-related optical bias, and self-calibrated optical sensing with international medical-device standardization.

Congratulations to Dr. Ariel Ashkenazi and Dr. Bat-Sheva Wagon-Galmidi

Fixler Lab congratulates Ariel Ashkenazi and Bat-Sheva Wagon-Galmidi on receiving their PhD degrees.We are proud of their achievements and wish them continued success in their scientific and professional careers.

New Optics Letters publication on pulse oximetry and IPL

Fixler Lab published a new paper in Optics Letters on reducing hypoxemia overestimation in pulse oximetry using the iso-pathlength point. The study investigates wavelength-dependent photon pathlength differences and proposes IPL-based measurement as a physics-informed approach for improving pulse-oximetry robustness. Link

Prof. Fixler gives TAU Light–Matter Interaction seminar

Prof. Dror Fixler delivered a Light–Matter Interaction seminar at Tel Aviv University. The talk focused on how internal structure in opaque multilayer media is encoded in externally measured optical signals, and how inverse modeling can translate diffuse optical responses into quantitative information.

Latest Publications

Ultrasensitive optoelectronic biosensor arrays based on twisted bilayer graphene superlattice

We present an ultrasensitive, amplification-free biosensor integrating 9.4° twisted bilayer graphene (tBLG) with Au nanodisks and CRISPR-Cas12a. By aligning tBLG’s van Hove singularity with plasmonic resonance, we achieved a 7-fold photocurrent enhancement and sub-femtomolar nucleic acid detection (44.63 aM). Validated with lung cancer samples, this hybrid platform offers a scalable, real-time solution for precision diagnostics with ultralow detection limits.